Biomedical & Clinical Informatics Lab

Department of Computational Medicine & Bioinformatics

Identifying peaks in Chip-Seq data using sparse deconvolution

Chromatin immunoprecipitation followed by DNA sequencing (Chip-Seq) is a methodology used to survey the interactions between the DNA and protein. It can also be used for mapping the genomic location of transcription-factor binding sites, histone modification chromatin remodeling enzymes and so on. This kind of mapping has some challenges in biology as well as computational analysis. The goal of this project is to determine the locations of transcription factor binding sites using mathematical models.
The top figure shows the input Chip-Seq, the middle is the smoothed input and the bottom figure shows the detected peaks.